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Analytics cookies to view the content. Organ damage including kidneys, brain and heart.

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Low plasma C3 levels suggest hyperactivation of the alternative complement pathway. However, medical professionals typically consider a combination of clinical symptoms, laboratory tests, and genetic analyses to confirm a diagnosis. Research by Professor David Kavanagh and his team in Newcastle, supported by Kidney Research UK, has shown that genetic information can help predict which patients diagnosed with atypical haemolytic uraemic syndrome aHUS will respond to treatment with a medication called eculizumab.

Patients with a suspicion of aHUS should receive eculizumab at a dose of mg once weekly for 4 weeks induction , and then mg once every other week maintenance. Official websites use. Vaughn Reynolds, an Army veteran and a retired federal air marshal, shares the story of his kidney disease journey.

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Atypical hemolytic-uremic syndrome is caused by genetic mutations, also known as pathogenic variants. Genetic changes in these genes increase the likelihood predisposition to developing aHUS, rather than directly causing the disease. Genetic mutations can be hereditary, when parents pass them down to their children, or they may occur randomly when cells are dividing.

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